![]() ![]() Therefore, tumor-associated myeloid cells have been designated as the culprits in cancer. The key role of myeloid cells in cancer is further evidenced by the fact that they negatively impact on virtually all types of cancer therapy. These studies further show that tumor-derived factors mold these myeloid cells into cells that support cancer initiation and progression, amongst others by enabling immune evasion, tumor cell survival, proliferation, migration and metastasis. Experimental and clinical studies show that most myeloid cells are kept in an immature state in the TME. Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages, dendritic cells and granulocytes. Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). ![]() ![]() Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium.Robin Maximilian Awad †, Yannick De Vlaeminck †, Johannes Maebe †, Cleo Goyvaerts ‡ and Karine Breckpot * ‡ ![]()
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